Pregnancy is a risk factor for the development of thrombophilic conditions. Thrombophilia (TF) during pregnancy is a pathological condition that develops as a result of hereditary or acquired anomalies in the hemostasis system and is characterized by a predisposition to the development of thrombosis.The gestational period is accompanied by physiological hypercoagulability and increases the risk of thrombosis by 5 to 6 times, which contributes to the realization of previously asymptomatic TF. The main changes in hemostasis during pregnancy include: an increase in platelet activity, an increase in the procoagulant properties of the endothelium, an increase in the content of coagulation factors, and a decrease in anticoagulant activity. In the conditions of maternal and fetal TF, there is a violation of implantation, as well as trophoblast proliferation, placentation and fetal growth, the development of systemic endothelial dysfunction, activation of the pro-inflammatory response and, as a result, conditions are created for the development of complications during childbirth. TF of various origins is dangerous for both the life of the mother and the fetus. Most often, during pregnancy, a woman does not suspect such an ailment and learns about the diagnosis after a comprehensive examination.

Постачальник даних: УкрІНТЕІ (Український Інститут науково-технічної експертизи та Інформації)

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