Modern market requirements for transportation of cargo flows according to the "quality, speed, and cost" criteria were studied. It was found that multimodal routes have the lowest delivery time, high reliability, and minimum transit time, which provides a more accurate level of control of costs, traffic schedules, and transport safety. It was determined that the effectiveness of multimodal transportation schemes depends on a degree of realization of resource capabilities and management technologies of a multimodal transport operator (MTO). The functional features and the MTO classification were generalized, which makes it possible to generate the MTO business model as a responsible integrator of transport and logistic processes, rather than consider it only from the point of view of the organizer of mixed transportation schemes. The technology of the organizational transportation process was systematized, based on which a system of strategic goals and key performance indicators (KPI) was developed, which makes it possible to determine the "bottlenecks" according to the main business processes of a multimodal transportation operator. The modified multifactor DuPont model was proposed, which makes it possible to establish the priority of factor evaluation of more time-stable indicators based on determining the levers of the MTO resource efficiency with greater coverage of factors. The performed research can become the basis for further development of the multimodal cargo transportation system based on the development of the model for optimal management of the MTO business processes.