The paper analyzes particular features of the clinical course, endoscopic changes, and dynamics of parameters, characterizing surfactant homeostasis in 60 patients with chronic obstructive bronchitis. In the treatment of 30 patients it was only the basic therapy options that were employed, other thirty patients received cyclopheron in addition to the above basic therapy. A positive dynamics of the illness was to be seen in all patients but those patients in whom the basic therapy treatments were supplemented with cyclopheron exhibited a higher clinical effect. The outlined positive dynamics has been shown to be accompanied by improvement of parameters for dynamic interphase tensiometry and rheometry of blood serum and expired air humidity condensate reflecting the state of surfactant homeostasis.