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Abaturov A. The role of vitamin D in metabolically unhealthy obesity in children [Електронний ресурс] / A. Abaturov, A. Nikulina // Здоров'я дитини. - 2023. - Т. 18, № 2. - С. 94-100. - Режим доступу: http://nbuv.gov.ua/UJRN/Zd_2023_18_2_6 Vitamin D deficiency is associated with impaired glucose tolerance, insulin resistance, metabolic syndrome, and an increased risk of developing type 2 diabetes. Aim: to study the role of vitamin D levels associated with single nucleotide variants (SNV) of the vitamin D receptor (VDR) gene in the development of metabolically unhealthy obesity (MUO) in children. Two hundred and ten obese children aged 6 - 18 years were examined. The main group (n = 125) was represented by children with MUO. The control group (n = 85) included children with metabolically healthy obesity (MHO). Whole genome sequencing (CeGat, Germany) was performed in 31 randomly selected children of the main and 21 children of the control group. The level of serum 25-hydroxyvitamin D (Synevo, Ukraine) was measured in all children. Verification of results: calculation of Spearman's correlation coefficient (r) and p-value for each variable. Conclusions: the development of cardiometabolic risk and vitamin D deficiency in obese children is associated with the presence of AA/AG genotypes SNV VDR rs12721365, rs2228572, rs2228570.
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