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Загальна кількість знайдених документів : 3 Представлено документи з 1 до 3 |
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| 1. | 
Sarnatskaya V. V. Optimization of physico-chemical properties of carbon enterosorbents and evaluation of their sorption activity for use in the treatment of paraneoplastic syndrome and other endogenous intoxications in cancer patients [Електронний ресурс] / V. V. Sarnatskaya, A. S. Sidorenko, D. A. Klymchuk, I. M. Khohulya, L. A. Yushko, V. N. Maslenniy, V. G. Nikolaev // Experimental oncology. - 2013. - Vol. 35, № 2. - С. 83-88. - Режим доступу: http://nbuv.gov.ua/UJRN/EOL_2013_35_2_4 Aim - development of carbon enterosorbents with optimal physical-chemical properties and high adsorptive capacity for their usage in the treatment of paraneoplastic syndrome and other endogenous intoxication in cancer patients. Methods: physical-chemical and biochemical methods of investigation. In the work it has been shown that performance of additional steam activation on pilot plant developed in R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology NAS of Ukraine, allows produce highly active granulated and fibrous carbon enterosorbents which possess well developed porous surface providing potent sorption potential toward compounds of hydrophilic and hydrophobic nature. Being placed in gastro-intestinal tract lumen these sorbents may cause certain effect on functional activity of detoxifying body systems and regeneration potential of many organs and tissues. Conclusion: The usage of carbon enterosorbents with optimal physical-chemical properties and high adsorptive capacity could be very perspective for correction of biochemical, immunologic, morphologic and hematological manifestations of paraneoplastic syndrome. | ||
| 2. |
Shton I. O. Chlorin e6 combined with albumin nanoparticles as a potential composite photosensitizer for photodynamic therapy of tumors [Електронний ресурс] / I. O. Shton, V. V. Sarnatskaya, I. V. Prokopenko, N. F. Gamaleia // Experimental oncology. - 2015. - Vol. 37, № 4. - С. 250-254. - Режим доступу: http://nbuv.gov.ua/UJRN/EOL_2015_37_4_5 Aim - to synthesize and to study for photodynamic activity a composite photosensitizer consisting of chlorin e6 and human serum albumin nanoparticles (HSA NPs). Starting from sorption-purified HSA, the albumin nanoparticles with a different degree of lysine residues cross-linking (10; 20; 40, and 100 %) were obtained by the coacervation method. The HSA NPs were used for synthesis of nanocomposites with chlorin e6 and fluorescein isothiocyanate (FITC)-labled preparations. Malignant lymphocytes of the MT-4 (human T-cell leukemia) line and normal lymphocytes of healthy donors served as cell targets. For photodynamic treatment, a semiconductor laser was exploited as a light source, and cell viability was assessed by MTT or trypan blue dye exclusion tests. For cell imaging and HSA NPs visualization, the fluorescence microscopy and transmission electron microscopy were applied, respectively. C57BI/6 mice were used in animal experiments. The absorption and fluorescence spectra of chlorin e6-HSA NPs composites were characterized, and by the electron microscopy investigation the size of NPs (nanospheres) was estimated: 100 - 120 nm. FITC-labled albumin preparations allowed to establish that HSA NPs have much higher exposition and concentration dependent affinity to malignant cell surface than initial HSA. In experiments with MT-4 cells on PDT activity of chlorin e6-HSA NPs, the nanocomposite effectiveness elevated along with increasing percentage of cross-linked aminoacid residues, and for the nanocomposite with 100 % of albumin cross-linking it exceeded the activity of free chlorin e6. In contrast to malignant cells, the complexation of chlorin e6 with HSA NPs decreased its photodynamic effect on normal human lymphocytes. Intravenous introduction of the chlorin e6-HSA NPs composite to mice showed prolonged circulation of the nanocomposite in blood in comparison with free PS. Conclusion: promising results obtained with chlorin e6-HSA NPs composites warrant conduction of full-fledged PDT studies in vivo using the nanocomposites as photosensitizers. | ||
| 3. |
Sarnatskaya V. V. Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma [Електронний ресурс] / V. V. Sarnatskaya, V. G. Nikolaev, L. A. Yushko, L. M. Paziuk, O. M. Karaman, N. I. Fedosova, D. L. Kolesnik, O. I. Dasyukevich, G. V. Gorbik, V. N. Maslenny, G. I. Solyanik // Experimental oncology. - 2015. - Vol. 37, № 4. - С. 255-261. - Режим доступу: http://nbuv.gov.ua/UJRN/EOL_2015_37_4_6 Aim - to study the correcting effects of microgranulated HSGD enterosorbent on hematological, morphological and biochemical indices of paraneoplastic syndrome in mice with highly angiogenic variant of Lewis lung carcinoma LLC/R9. The study was performed on male C57/BL6 mice with transplanted LLC/R9. Enterosorbent HSGD was administered daily at a dose of 0,625 g/kg for 2 weeks starting from 7<^>th | ||
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