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Malhame I. Communication from the ISTH SSC Subcommittee on Women's Health Issues in Thrombosis and Haemostasis: A Survey on Anticoagulation for Mechanical Heart Valves in Pregnancy. Recommendations and guidelines [Електронний ресурс] / I. Malhame, M. Othman, P. Casais, R. D'Souza, R. M. Wald, C. K. Silversides, M. Sermer, N. Shehata // Український журнал перинатологія і педіатрія. - 2021. - № 3. - С. 83-92. - Режим доступу: http://nbuv.gov.ua/UJRN/perynatology_2021_3_15 Patients with mechanical heart valves (MHV)s require life long anticoagulation to prevent throm boembolic complications (TECs). Women with MHVs in pregnancy experience an increased risk of severe maternal morbidity and mortality from both thrombotic and bleeding complications. A large international registry of pregnancies with MHVs revealed that valve thrombosis and maternal mortali ty occurred in 4,7 % and 1,4 % of women, respectively, and hemorrhage complicated 23 % of pregnancies [1]. Of importance, only 58 % of women with MHVs were free from serious adverse events during preg nancy compared with 79 % of women with bioprosthetic valves and 78 % of women with cardiac disease and no prosthetic valves [1].
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