New polyurethane-epoxy biodegraded polymeric compositions with osteotropic action are developed. The reactive oligomer-oligomer and oligomer-polymer mixtures containing urethane fragments, drug substances, and hydroxyapatite are used to obtain composition materials. Such composition design provides the solution of post-operation complication problems and the bioactivity-biocompatibility of the composition. The dependences of mechanical properties of the composition material on the polyurethane/epoxy oligomer ratio, polyurethane molecular mass, urethane group concentration, and hydroxyapatite content are analyzed.