The liver affected by different toxicants in most cases responds in a similar way histomorphologically known as microcirculation disorder, the development of inflammatory area infiltrated with mononuclear cells, prime elements structure disorder, destructive-dystrophic changes of hepatocytes, which in some cases turn out necrotic. The character and degree of the hepatic response depends on a chemical component, exposition time and gender. Phenol and formaldehyde caused the most considerable alterations in the rats' livers, whereas the rats subjected to ammonia and sulfur dioxide intoxication had the least alterations in their livers. The male rats had more considerable lesions in their livers than the female ones.

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