Intoxication of rats of both sexes three months in duration leads to development of cytolysis and hepatocellular insufficiency, with females displaying a higher degree of it. At the same time, fluorine promotes development of hypolipoperoxidation in males. In females, unlike males, intensification of LPO tended to grow higher and was to be seen with both agents. SOD activation has been revealed in exposure of females to zinc and of males to both fluorine and zinc. Also revealed in the animals was activation of catalase, especially so in males. Activation of membranodestructive processes in the liver of test animals brings about a decline in the pharmacometabolizing function of the organ.

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