We analyzed in detail the quantum parameters of evoked inhibitory postsynaptic currents (eIPSC) recorded from synaptically connected cultured cortex neurons using a whole-cell patch-clamp technique. The IPSC were evoked using minimum extracellular stimulation of a presynaptic unit with a frequency of <$E 0,2~roman sec sup -1> at the holding potential of -80 mV. Amplitude histograms for eIPSC demonstrated clearly detectable equally spaced peaks. For each histogram, we used a method based on autocorrelation analysis and Monte Carlo simulation, to determine whether peaks in the amplitude histograms can result due to finite sampling from a sum of the Gaussian distributions. The autocorrelation function allowed us to measure the peak spacing (and, hence, the mean quantum size) for each histogram; this parameter was found to be 10 pA.

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