The effect of an antiepileptic drug, ethosuximide, on fusion of synaptic vesicles with the synaptosomal plasma membranes was studied. It was shown that ethosuximide increases the rate of the <$E roman Ca sup 2+>-dependent fusion reaction. We found that ethosuximide-induced fusion of synaptic vesicles with the plasma membrane in a <$E roman Ca sup 2+>-free medium is much lower than the <$E roman Ca sup 2+>-induced effect under the same conditions. Thus, the fusion-inducing effect of ethosuximide is mostly <$E roman Ca sup 2+>-dependent. Ethosuximide-evoked fusion was suppressed by pentylenetetrazol.

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