We observed 367 children with chronic viral hepatitis Delta (CVHD) and В (CVHB) and found strict secondary T-immunodcficiency, more expressed in children with CVHD. We have found also the most characterizing changes of lymphocytes subpopulation and natural killer-cells depending on etiology of CVH. As for CVHD it is characterized by more significant decrease in <$E roman CD sub 4>-lymphocytes, as for CVHB - <$E roman CD sub 8>-lymphocytes. The above mentioned changes of lymphocytes subpopulation in patients with CVHD and CVHB show different pathological mechanisms of these two diseases, that should be taken into account treating such patients.

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