Insulin edema (IE) has been known for a long time as one of complications caused by insulin therapy, but even today its pathogenesis stays unclear, and epidemiology unknown. IE incidence in patients over 15 years of age receiving treatment in the year 2003 for diabetic ketoacidosis (DKA) in the city of Donetsk (adult population 858 200) has been retrospectively studied according to clinical archives and national diabetics register data. Presented are three own observations on the development of IE after DKA treatment. 13 (17 %) out of 76 DKA patients had IE. Keeping in mind reoccurring DKA incidents - 16 %. During IE the known duration of Diabetes Mellitus came out to be 5 years on average, and did not differ from insulin therapy duration, whereas the Diabetes Mellitus duration in non DKA group without edemas exceeded the continuance of insulin treatment by over two years (<$E roman P~<<~0,05>).

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