The effect of cationic drug chlorpromazine (CPZ) on the structural state of model lipid membranes composed of zwitterionic phospholipid phosphatidylcholine (PC) and anionic phospholipid cardiolipin (CL) in molar ratios 8:2 and 3:2 has been investigated using the indicator dye Neutral Red (NR). CPZ incorporation into the PC/CL (8:2) liposomes led to the increase of NR partition coefficients. This effect was interpreted in terms of drug-induced membrane disordering. In contrast, CPZ association with PC/CL (3:2) lipid bilayers suppressed the dye partition which was assumed to be a result of lipid phase transition.

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