Aim: To study the expression of cathepsin L in nasopharyngeal carcinoma (NPC), and analyze its relationship with clinicopathologic factors. Methods: The expression of cathepsin L was determined immunohistochemically in NPC, adjacent normal nasopharyngeal tissues and metastatic cervical lymph nodes. The correlation between its protein expression and clinicopathologic parameters as well as with long term follow-up data in NPC was analyzed. Results: The protein of cathepsin L was overexpressed in 47 % primary tumor tissues, and in 89 % metastatic cervical lymph node samples. Overexpression of cathepsin L was found to correlate with lymph node metastasis (p = 0,04) and distant metastasis (p = 0,01), and marginally with clinical stage and T classification, but not with patient age, gender and histological classification of tumor. Patients with overexpression of cathepsin L in tumor tissue had worse 5-year survival than those without such expression pattern (p = 0,033). Multivariate survival analysis showed that cathepsin L protein expression level had a marginal significant correlation with prognosis of NPC. Conclusion: Cathepsin L is a potential biomarker for prognosis of NPC and contributes to NPC metastasis.

Індекс рубрикатора НБУВ: Р569.682.4-3 + Р569.682.5-3

Рубрики:

Пухлини носа і придаткових пазух

Пухлини глотки

Шифр НБУВ: Ж14160 Пошук видання у каталогах НБУВ 

---

  Якщо, ви не знайшли інформацію про автора(ів) публікації, маєте бажання виправити або відобразити більш докладну інформацію про науковців України запрошуємо заповнити "Анкету науковця"