In experiments on isolated hearts of guinea-pig, perfused under Langendorff preparation, possible protection of hearts from the reperfusion injury by annexin II was studied. It has been shown that the heart and oxygen metabolism disturbances, stimulated by global 20 min ischaemia and reperfusion, were essentially decreased by a preliminary application of annexin II. It improved cardiac recovery (in 40 min of heart reperfusion, LV developed pressure was 64 % as compared to 48 % in that at control; dP/dtmax and dP/dtmin by 75 % and 63 % accordingly against 66 % and 45 % in control). We infer that annexin II essentially decreases postreperfusion disturbances of cardiac contractility and noneffective oxygen utilization by the heart tissue xdue to the protection effect on cells' membranes, on the one hand, and binding <$E roman Ca sup 2+> and blocking up the opening of a mitochondrial permeability transition pore, on the other hand.

• Шиманська Тетяна Віталіївна (медичні науки)
• Надточій Сергій Миколайович (біологічні науки)
• Бабійчук Вікторія Станіславівна (біологічні науки)

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