We studied the total protein kinase C activity and the distribution of a protein kinase C isoform in the subcellular fraction of adrenal cortex and human adrenal tumors. Protein kinase C activity of the membrane fraction and nuclei of tumors was 1,5 times higher than the activity of adjacent conditionally normal tissue. Translocation of a protein kinase C isoform from cytosol to the membrane fraction was detected in adrenal tumors. The distribution of the enzyme in nuclei fractions was not changed and was independent of a tissue origin. Our results suggest a possible role of protein kinase C in tumorogenesis in human adrenal gland.

• Ковзун Олена Ігорівна (1968–) (медичні науки)

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