Gerashchenko G. V. Screening of epigenetic and genetic disturbences of human chromosome 3 genes in colorectal cancer / G. V. Gerashchenko, V. V. Gordiyuk, I. Ya. Skrypkina, S. M. Kvasha, O. O. Kolesnik, D. D. Ugryn, T. V. Pavlova, E. R. Zabarovsky, A. V. Rynditch, V. I. Kashuba // Укр. біохім. журн.. - 2009. - 81, № 4 (спец. вип.). - С. 81-87. - Бібліогр.: 22 назв. - англ.DNA microarray technology comprising NotI-linking clones was used in a large-scale study of genetic and epigenetic changes in colorectal cancer. Analysis of samples from 24 patients revealed methylation, deletions, and amplifications in 137 of 181 NotI clones. For 27 genes/loci, these changes occurred in more than 30 % of the tumor samples, suggesting that these genes are involved in the development of colorectal cancer. An analysis of the methylation status of CpG island of the ITGA9 gene/loci by bisulfite sequencing confirmed the NotI microarray data on the gene/loci methylation in colorectal cancer. Aberrations in 19 genes/loci were unknown previously. Their characterization may help ascertain the mechanisms responsible for colorectal cancer development and identify novel diagnostic and prognostic markers. Індекс рубрикатора НБУВ: Е70*445.4 + Р569.433.33-2
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