Aim - preclinical study of the specific anticancer pharmacological activity of the formulation containing active substance 3,3'-diindolylmethane (DIM), cod liver oil, polysorbate 80 and alpha-tocopherol acetate (vitamin E), in vivo in a xenograft animal model of LNCaP. The DIM, cod liver oil, polysorbate 80 and alpha-tocopherol acetate (vitamin E) formulation was intragastricaliy administered to BALB/c-nude (nu/nu) mice during 33 days post inoculation at the dose of 133 mg/kg/day. Antitumor activity of the test drug was estimated by the rate of tumor growth inhibition (T/C % - treated versus control), dividing the tumor volumes from treatment groups with the control groups. Statistically significant tumor xenograft regressions have been shown in group which received the DIM, cod liver oil, polysorbate 80 and a-tocopherol acetate (vitamin E) on the 37<^>th day of observation post inoculation. The highest antitumor activity was achieved on the 39<^>th day (T/C = 16,8 %). Therapeutic effect lasts for 6 days after the end of therapy period. Conclusion: our findings demonstrate inhibitory effect of the formulation on tumor development in the xenograft animal model due to the tumor growth rate reduction.

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