A comparative study of enzyme activity features of thymidilate "salvage pathway" synthesis in blood serum and tissues of different age patients with gastric cancer (T_3-4N_0-xM₀) was carried out. Aim - to evaluate the diagnostic relevance of thymidilate metabolism enzymes activities and their association with tumor growth. Enzymes activities were determined by the radioisotope method and spectrophotometrically in tumor tissues and blood serum of 74 patients. It was demonstrated that thymidine phosphorylase activity in gastric tumors is lower by 2,6 times as compared to non-neoplastic mucosa of resection margin. This being accompanied by decrease of its activity in the blood serum (from 47,9 +- 2,6 to 14,65 +- 2,4 nmol/min-mg, p << 0,001). An increase of thymidine kinase activity was revealed both in tumor tissues (more than 3,5 times) and in blood serum (from 3,9 +- 0,7 nmol/mg-h, to 6,8 +- 1,0 nmol/mg-h, p << 0,01). Changes in their activity in the postoperative period depended on the type of surgical procedure and tumor eradication. Conclusion: it could be suggested that control of individual dynamics of the enzymes activities in blood serum may be used as informative tool for monitoring of patients and treatment optimization.

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