We have examined 23 hypertensive type 1 diabetes patients with microangiopathy: age 20,34 +- 2,05 years, duration of the disease 11,56 +- 3,18 years, HbA1c 10,74 +- 1,52 %, fasting blood glucose 11,26 +- 2,1 mmol/l, total cholesterol 5,61 +- 0,7 mmol/l, HDL 0,97 +- 0,17 mmol/l, LDL 3,56 +- 1,02 mmol/l, triglycerides 2,64 +- 0,51 mmol/l, systolic blood pressure 162,17 +- 12,95 mmHg, diastolic blood pressure 100,87 +- 5,36, 52,17 % treated with antihypertensive drugs, 47,82 % - nontreated. 10 non-hypertensive type 1 diabetic patients with microangiopathy: age 20,3 +- 2,21 years, duration of the disease 10,87 +- 3,72 years, HbA1c 9,88 +- 1,76 %, fasting blood glucose 10,08 +- 2,68 mmol/l, total cholesterol 5,15 +- 1,41 mmol/l, HDL 1,11 +- 0,24 mmol/l, LDL 3,11 +- 1 mmol/l, triglycerides 2,3 +- 0,56 mmol/l; and 28 healthy control subjects: age 19,96 +- 2,06 years, HbA1c 5,33 +- 0,45 %, fasting blood glucose 4,6 +- 0,57 mmol/l, total cholesterol 4,14 +- 0,51 mmol/l, HDL 1,34 +- 0,23 mmol/l, LDL 2,63 +- 0,4 mmol/l, triglycerides 1,46 +- 0,29 mmol/l. 52,17 % hypertensive type 1 diabetic patients with microangiopathy have proliferative diabetic retinopathy, 30,43 % - preproliferative diabetic retinopathy, 13,04 % - non-proliferative, 100 % - diabetic nephropathy IV (Mogensen C.E.). 30 % non-hypertensive type 1 diabetic patients with microangiopathy have proliferative diabetic retinopathy, 10 % - preproliferative diabetic retinopathy, 40 % - non-proliferative, 50 % - diabetic nephropathy IV, 50 % - diabetic nephropathy III (Kohner Е., Porta M.). All patients don't use hypolipidemic drugs. Serum levels of fibronectin have been determined by immunoenzyme assay. The data have been presented as means +-SD. Statistical analysis has been performed using the Mann - Whitney U-test, Pearson rank correlation coefficient, multiple regression analysis. Serum level of fibronectin in hypertensive type 1 diabetic patients with microangiopathy has been 382,57 +- 39,73 pmol/ml, non-hypertensive diabetic patients - 295,96 +- 83,91 pmol/ml, in control group - 202,71 +- 47,34 pmol/ml. We have found an increased serum level of fibronectin in hypertensive type 1 diabetic patients with microangiopathy compared to control group (88,72 %, p << 0,01), in non-hypertensive type 1 diabetic patients with microangiopathy compared to control group (46 %, p << 0,01) and in hypertensive type 1 diabetic patients with microangiopathy compared to group of non-hypertensive diabetic patients (29,26 %, p << 0,01). Also, the level of fibronectin has correlated with HbA1c (r = 0,82; p << 0,05), fasting blood glucose (r = 0,78; p << 0,05), total cholesterol (r = 0,58; p << 0,05), HDL (r = -0,69; p << 0,05), LDL (r = 0,68; p << 0,05), triglycerides (r = 0,64; p << 0,05) in hypertensive type 1 diabetic patients with microangiopathy and HbA1c (r = 0,49; p << 0,05), fasting blood glucose (r = 0,58; p << 0,05), total cholesterol (r = 0,28; p << 0,05), HDL (r = -0,77; p << 0,05), LDL (r = 0,3; p << 0,05), triglycerides (r = 0,48; p << 0,05) in non-hypertensive type 1 diabetic patients with microangiopathy.

• Могильницька Лілія Анатоліївна (медичні науки)

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