Diabetes is a leading cause of global morbidity and mortality. As genetic inheritance is involved in the pathogenesis of the disease, polymorphism of various genes and genetic mutations could be implicated in the phenotype of the disease manifestation. Recently studies on inheritance of type 2 diabetes mellitus have revealed the observation that the offspring of diabetic parents have forewarning findings of altered neural and autonomic functions even in their non-diabetic state. Therefore, this study has been designed to assess any change in nerve conduction parameters of the motor component of the median nerve in the same population. To assess the median motor nerve conduction parameters in non-diabetic offspring of type 2 diabetic and non-diabetic parents and infer the changes in the study population by comparing the groups mentioned above. The Nerve conduction study of the median nerve (motor component) was carried out on both hands of 60 non-diabetic volunteers aged between 18 - 25 (30 offspring of type 2 diabetic parents and 30 offspring of non-diabetic parents with equal number by gender in each group) in normal BMI range. The comparison between the groups revealed no significant difference in latency, amplitude and conduction velocity in the motor component of the median nerve. Conclusion: in our study we have observed that there is no significant difference in the motor nerve latencies between the groups. Unlike the observations of altered visually evoked potentials and autonomic impairment in similar population by other studies, the observation of non-involvement of the somatic nerve could be discussed as a sequel to glycation of neural structures that could impair the neuronal activity.

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