Chekhun V. F. Antitumor and genotoxic effects of lactoferrin in Walker-256 tumor-bearing rats / V. F. Chekhun, D. M. Storchai, I. N. Todor, T. V. Borikun, N. Yu. Lukianova // Experimental Oncology. - 2018. - 40, № 3. - С. 200-204. - Бібліогр.: 28 назв. - англ.Aim - to investigate the influence of exogenous lactoferrin (LF) on tumor growth, energy and lipid metabolism of Walker-256 carcinosarcoma and to assess genotoxic effects of LF. The study was performed on Walker-256 tumor-bearing rats. Total lipids and phospholipids were determined by thin-layer chromatography. Comet assay was used to investigate the genotoxic effects of LF. Daily i.p. administrations of exogenous LF at concentrations of 1 mg/kg and 10 mg/kg starting from the 4<^>th day after tumor transplantation suppressed growth of Walker-256 carcinosarcoma by almost 44 %. After treatment with recombinant LF in both doses, the phospholipid composition of Walker-256 carcinosarcoma cells was changed (3-fold increase of phosphatidylethanolamine, 3.4-fold increase of phosphatidylcholine, and 1.8-fold increase of sphingomyelin, while the cardiolipin content decreased by 67 %. Exogenous LF was not genotoxic for bone marrow cells (as assessed by the ratio of PCE/NCE, number of micronuclei) and peripheral blood lymphocytes (percentage of DNA in the tail of a comet) in Walker-256 carcinosarcoma-bearing rats. Conclusion: exogenous LF caused the inhibition of Walker-256 carcinosarcoma growth and a decrease in the microviscosity of plasma cell membranes, and exerted no genotoxicity toward bone marrow cells and peripheral blood of experimental animals. Індекс рубрикатора НБУВ: Р56-20 + Р56-52
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