Aim - to study the expression of adhesion markers (E-cadherin, beta-catenin and vimentin) associated with epithelial-mesenchymal transition (EMT) and their role in progression of endometrial carcinoma (EC). Expression of E-cadherin, beta-catenin and vimentin was studied immunohistochemically in the samples of surgical material of 55 EC patients stage I - III. The proliferation index was determined by flow cytometry. In the group of vimentin-negative EC, tumors of low differentiation grade and deep invasion in myometrium as well as high expression of E-cadherin and beta-catcnin prevailed compared with the cases with high expression of vimentin. In addition, in EC with high expression of vimentin, an increase in the number of cells with expression of E-cadherin in the cytoplasm (78,9 +- 3,6 %) and beta-catenin with cytoplasmic-nuclear localization (73,7 +- 3,2 %) was observed compared with these indices in vimentin-negative tumors (45,4 +- 4,2 %, p << 0,001 and 54,5 +- 2,6 %, respectively, p << 0,005), which may indicate EMT-associated changes in EC with high expression of vimentin. Conclusions: the progression of the endometrioid carcinoma may occur in the setting of various molecular changes, in particular, with decreased expression of E-cadherin and beta-catenin and high expression of vimentin, or in the absence of vimentin, utilizing other mechanisms of regulation of proliferative and metastatic potential.

• Юрченко Наталія Петрівна (медичні науки)
• Бучинська Любов Георгіївна (медичні науки)

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