The presence of interconnections between the parameters of the nervous, endocrine and immune systems within the framework of the triple complex is well known. However, data on the nature (synergism or antagonism) of the influence of the sympathetic and vagus link of the autonomic nervous system on the individual parameters of immunity are ambiguous. One of the approaches to solving this problem is to compare immunity parameters in individuals with different states of the autonomic nervous system. This is what determined the purpose of this study. The experiment is at 60 female and 50 male white rats Wistar line weighing 210 - 320 g. Of these for 10 animals of each sex not subjected to any influences and others within 6 - 7 days were subjected to different stressing or adaptogenic manipulations. The day after the completion of manipulations in all rats determined parameters of heart rate variability and leukocytogram. The next day, the animals were decapitated, for the purpose of collecting blood. The plasma levels of the hormones of adaptation were determined: corticosterone, triiodothyronine, thyroxine and testosterone; as well as electrolytes: calcium, phosphates, sodium and potassium for evaluation parathyrin, calcitonin and mineralocorticoid activities. On the state of the phagocytic function of microphages and macrophages judged by phagocytic index, microbial number and index of killing regarding museum culture Staphylococcus aureus. Among the parameters of immunogram determined the relative amount of blood population of T-cells, their theophylline resistant and sensitive subpopulations as well as the population of B-lymphocytes and Natural killers. From the spleen and thymus did smears for counting splenocytogram and thymocytogram. For the latter, as well as immunocytogram and leukocytogram we calculated entropy. Three groups were formed according to the integral state of the autonomic nervous system evaluated by Baevskiy Stress-index. The eutonia was confirmed in 25 rats (14 males and 11 females). In 33 rats (12 males and 21 females) vagotonia was confirmed, whereas in 52 rats (24 males and 28 females) sympathicotonia was observed. Discriminant analysis detected 17 parameters, the totality of which three states of autonomous regulation differ significantly. In particular, in addition to the three HRV parameters, by definition, three endocrine parameters, two parameters of thymocytogram, five parameters of splenocytogram and three immune parameters of blood appeared to be characteristic. Qualitatively different states of the autonomic nervous system of rats are accompanied by a characteristic constellation of endocrine and immune parameters, one set of which is subordinate to the opposite effects of the sympathetic and vagus link, whereas the other set contains parameters that are not significantly different in sympathicotonic and vagotonic animals and are characteristic of the eutonia.

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