Aim - trace elements play a key role in human metabolism. The aim of the present study was to measure essential trace elements in the serum of patients with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). 32 patients with ALL and 16 patients with AML were studied. The control group consisted of 36 subjects. Serum levels of the trace elements selenium, copper and zinc were measured by spectrophotometry. The mean of copper concentrations in the groups of patients with AML and ALL was significantly higher than in the control group (p << 0,0001), whereas serum levels of selenium and zinc were significantly lower in AML patients (p << 0,0001). Also in ALL patients the levels of selenium and zinc were significantly decreased compared with the control group (p << 0,0001; p = 0,0003). Conclusion: our results indicate that the levels of zinc and selenium are significantly decreased and copper levels are significantly increased in the serum of patients with acute leukemia (AML, ALL).

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