Prylutska S. V. Antitumor effects and hematotoxicity of C60-Cis-Pt nanocomplex in mice with Lewis lung carcinoma / S. V. Prylutska, O. V. Lynchak, V. V. Kostjukov, M. P. Evstigneev, O. V. Remeniak, V. K. Rybalchenko, Yu. I. Prylutskyy, U. Ritter, P. Scharff // Experimental Oncology. - 2019. - 41, № 2. - С. 106-111. - Бібліогр.: 50 назв. - англ.Background: cisplatin (Cis-Pt) is a widely used anticancer drug but its therapeutic efficiency is limited by hemato-, cardio-, hepato-, nephro- and neurotoxicity. Complexation of Cis-Pt with C60 fullerene nanoparticle will allow to enhance the antitumor activity of the drug and to reduce its side toxic effects. Aim - to estimate the antitumor effects of C60-Cis-Pt nanocomplex in Lewis lung carcinoma (LLC) and analyze hematological toxicity in tumor-bearing mice. Complexation of C60 fullerene and Cis-Pt molecule was studied by computer simulation. C60-Cis-Pt nanocomplex was i.p. injected to LLC-bearing mice in a total dose of 7,5 mg/kg (C60:Cis-Pt as 3,75:3,75 mg/kg). The survival of tumor-bearing mice and the relative reduction of tumor weight was recorded. Blood indices were determined using the Particle Counter PCE210 automatic hematology analyzer. Computer simulation demonstrated the formation of C60-Cis-Pt nanocomplex in physiological medium and its stability due to the hydrophobic interactions. Treatment with C60-Cis-Pt nanocomplex increased survival time of LLC-bearing mice by 32 %, normalized hemoglobin content (up to 100 g/l), erythrocyte and platelet count as compared to the untreated LLC-bearing mice. Tumor weight decreased by 35,5 %; the mitotic index of tumor cells decreased by 78 %, and apoptotic index increased by 75 %. The revealed effects of the C60-Cis-Pt nanocomplex were more pronounced than the effects of Cis-Pt or C60 fullerene alone in equivalent dose. Conclusion: treatment with C60-Cis-Pt nanocomplex prolonged the survival of LLC-bearing mice and reduced anemia in LLC-bearing mice. Індекс рубрикатора НБУВ: Р569.423-52
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