The aim of the work was to study clinical and pathological factors affecting the prognosis of the disease in patients with stage III - IVA-B oral squamous cell carcinoma (OSCC). A retrospective review of medical records of 234 patients with stage III - IVA-B OSCC was performed in order to study the impact of clinical and pathological factors on disease-free survival (DFS) and overall survival (OS). Multivariable analysis of clinical factors revealed a statistically significant effect of stage IVA-B and the presence of surgical complications on DFS (hazard ratio (HR) = 4,9 (95 % confidence interval (Cl) 2,9 - 8,3), p << 0,001; HR = 1,6 (95 % CI 1,0 - 2,6), p = 0,047), respectively. Stage IVA-B, the presence of surgical complications and the retromolar trigone subsite were found to have a statistically significant impact on OS (HR = 4,0 (95 % CI 2,5 - 6,5), p << 0,001; HR = 1,8 (95 % CI 1,1 - 2,8), p = 0,01; HR = 1,9 (95 % CI 1,1 - 3,2), p = 0,02), respectively. Multivariable analysis of pathological factors showed a statistically significant effect of positive resection margins, the multiple lymph node involvement and high-grade tumor on DFS (HR = 3,7 (95 % CI 2,0 - 6,6), p << 0,001; HR = 4,3 (95 % CI 2,8 - 6,7), p << 0,001; HR = 1,6 (95 % CI 1,1 - 2,2), p = 0,01), respectively. Besides, positive resection margins and multiple lymph node involvement were found to cause a statistically significant impact on the OS (HR = 3,6 (95 % CI 2,0 - 6,5), p << 0,001; HR = 3,7 (95 % CI 2,5 - 5,6), p << 0,001), respectively. A tumor grade tended to worsen OS (HR = 1,4 (95 % CI 1,0 - 1,9), p = 0,053). Conclusion: stage IVA, B, the presence of surgical complications, the retromolar trigone subsite, positive resection margins, multiple lymph node involvements and high-grade tumor were found to be significant clinical and pathological prognostic factors in patients with stage III - IVA-B OSCC.

• Кравець Ольга Вікторівна (медичні науки)

  Якщо, ви не знайшли інформацію про автора(ів) публікації, маєте бажання виправити або відобразити більш докладну інформацію про науковців України запрошуємо заповнити "Анкету науковця"