Purpose. To define the relationship between economic growth, various types of environmental pollution and the use of natural resources in Dnipropetrovsk region, to justify measures to reduce the adverse impacts of industry on the environment. Methodology. The methodology of research on the relationship of economic growth, environmental pollution and the use of natural resources in the region is based on the methods of scientific knowledge, specifically observation, comparison, analysis, dialectical method, statistical analysis are used. Findings. The effect of relative decoupling by types of environmental pollution and resource use at the regional level in the general dynamics for 2013 - 2017 was not found. It is coincides with the national trend and indicates the existence of problems for the region and the state in achieving sustainable development. Absolute decoupling was found at the regional level for all types of environmental pollution in 2017 compared to 2013 - 2014, fuel use for production and household needs, natural gas and motor gasoline in 2013 - 2017. There are more cases of absolute decoupling at the level of Dnipropetrovsk region than at the state level. According to the method by P. Tapio, between the economic growth of the region and the majority of types of pollution in 2013 - 2017 there was predominantly recessive coupling. Between the growth rates of the gross regional product of Dnipropetrovsk region and carbon dioxide emissions in 2016 was an expansive negative decoupling. Between economic growth and resource consumption in the region there was found systemic overcoupling on fresh water in 2014 and 2016, volumes of harvesting liquid wood in 2015 - 2016, firewood for heating in 2013 - 2016, and fuel briquettes and wood pellets and other natural raw materials in 2015 and 2017. Originality. Decoupling factors were studied at the system level, which estimate a degree of relation between environmental pollution, resource use and economic growth. With the lack of economic growth, there is found a phenomenon of negative decoupling - overcoupling, which indicates high rates of resource use. Practical value. The results of the decoupling analysis are recommended to be used in the formation and adjustment of strategic programs for the sustainable development of Dnipropetrovsk region.

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