The objective of the study was to assess the disposition and challenges of students towards teaching and learning of biochemistry through WhatsApp. The study was a cross-sectional survey which had 200 level (Second Year) and 400 level (Fourth Year) students of biochemistry as respondents. Data collection was done using a selfdeveloped questionnaire administered through the WhatsApp group created for learning and collected through a designated e-mail address. Data analysis was carried out using the mean and standard deviation setting a mean score of 2,5 as a benchmark for accepting or rejecting statements made in the questionnaire. The study revealed that students had a level of openness to using online teaching resources for biochemistry; they do not believe that the use of WhatsApp for teaching and learning of biochemistry as a means of alternative to face to face classroom interaction will be effective in imparting the right knowledge in biochemistry. Several challenges identified are linked to not just money but is hinged around the curriculum structure of the biochemistry programme. Conclusion: it is concluded that WhatsApp represents a potential means of instruction but may be hampered by challenges hinged on the curriculum structure of biochemistry.

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