There is no available treatment or vaccine for HIV/AIDS, and health education has, therefore, become a top priority in the prevention of disease. It is of great importance to have sufficient information about HIV/AIDS and how to control infection. This study was conducted to determine the effect of the Infectious Disease Nursing course on nursing students' knowledge and attitudes towards AIDS. This quasi-expedmental study was carried out between February 12 - May 28, 2019 and included 50 nursing students who were taking the Infectious Disease Nursing course for the first time and attended the pre-test and post-test. The data were collected using a Personal Information Form and the AIDS Knowledge and Attitude Scale. Descriptive statistics, the paired sample t-test and Pearson correlation analysis were used in the evaluation of the data. Among the students who participated in the study, 94,0 % of students were at the age of 18 - 21 years; 80,0 % of students were females; 54,0 % of students stated that they had adequate knowledge of AIDS; 78,0 % of students stated that they did not want to provide care to individuals with HIV/AIDS. There was found a significant strong positive correlation between the mean pre- and post-education scores for the AIDS Knowledge and Attitude Scale (p << 0,05, P = 0,34; p << 0,01, r = 0,72). There was a significant, weak negative correlation between the mean post-education AIDS total Attitude mean score and the status ofhaving contact with a patient with HIV/AIDS and wanting to provide care for a patient with HIV/AIDS (p << 0,05, r = -0,31), and a significant weak positive correlation between the status of wanting to provide care for a patient with HIV/AIDS and seeing people with HIV/AIDS as a threat (p << 0,01; r = -0,50). Conclusions: all the students benefited from the information on AIDS and became informed due to attending the Infectious Diseases Nursing course and their attitudes towards AIDS improved.

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