Single nucleotide variants (SNVs) of the ghrelin (GHRL) gene are accompanied by the production of a defective preproghrelin protein, which can lead to the development of obesity and metabolic disorders. The purpose was to study the associations of SNVs of the GHRL gene in children with the development of various obesity phenotypes. Two hundred and fifty-two obese children aged 6 - 18 years were examined. The main group (n = 152) was represented by patients with metabolically unhealthy obesity (MUO). The control group (n = 100) included children with metabolically healthy obesity (MHO). Whole genome sequencing (CeGat, Germany) was performed in 31 children of the main group and 21 controls. Serum levels of interleukin-1<$E beta> were measured using a hemiluminescent immunoassay, interleukin-6 - by enzyme-linked immunosorbent assay (Synevo, Ukraine). Conclusions: the missense variants rs696217 and rs4684677 of the GHRL gene are SNVs highly associated with obesity and the development of metabolic disorders.

• Абатуров Олександр Євгенович (1956–) (медичні науки)
• Нікуліна Анна Олексіївна (медичні науки)
• Нікуліна Анастасія Станіславівна (технічні науки)

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