Індекс рубрикатора НБУВ: Р266 + Р56-52

Рубрики:

Вакцини і сироватки

Онкологія

Шифр НБУВ: Ж22412/а Пошук видання у каталогах НБУВ 

For the purpose to determine the effectiveness of vaccination with anthrax STI vaccine of horses some indices of blood like: content of overall proteins in blood serum; phagocytic activity of leukocytes, lyzocyme activity of the blood serum were studied. The level of the anti-anthrax antibodies, synthesized in organism of the vaccinated animals was investigated by the reaction of passive hem agglutination. In experimental animals (3 horses), considering the deviations determines, following indices have been found to be increased: intensity of leukocyte phagocytosis (control - 0,15 - 0,2; after immunization - 0,56 - 1,24); lyzocyme activity; level of overall protein in the blood serum. The titers of the anti-anthrax antibodies, developed in the horse organism (1:80 - 1:160) exceeded the indices of the same antibodies 4 - 8 times, before vaccination (1:10 - 1:20). Elevated number of leukocytes, erythrocytes thrombocytes, and level of hemoglobin were found in the vaccinated animals. Intensive increase of the hematological indices and development of the specific anti-anthrax antibodies determine the immunity of an organism using the STI vaccine.

Індекс рубрикатора НБУВ: Р569.423-5

Рубрики:

Пухлини легенів

Шифр НБУВ: Ж14160 Пошук видання у каталогах НБУВ 

Aim - to investigate the anticancer efficiency of the xenogeneic vaccine in different tumor models and to assess the possibility whether level of antibodies (Ab) specific for vaccine's proteins can be used as an indication for its use. Mice with Lewis lung carcinoma (LLC), Ehrlich carcinoma (EC) or Sarcoma 37 (S37) were immunized with a xenogeneic anticancer vaccine based on chicken embryo proteins (CEP) and its anticancer activity was examined. The level of specific Ab in the blood serum of non-immunized tumor-bearing mice was studied by ELISA. CEP application statically significantly inhibited the growth of LLC (the index of tumor growth inhibition was 42,10 - 53,13 % depending on the day of tumor growth); vaccinated mice with EC showed significant tumor growth inhibition and life prolongation by 34,48 %. Among mice with S37, there was noticed no antitumor effect. The number of tumorbearing nonimmunized mice which have had preexisting CEP-specific Ab did not differ depending on the tumor model. The level of CEP-specific Ab among mice with LLC and EC increased with the growth of the tumor volume, but it decreased among mice bearing S37. Probably, the low level of CEP-specific Ab alongside huge tumor burden shows it is futile to apply the CEP-based vaccine. Conclusion: different tumor strains vary in their susceptibility to CEP-based vaccine. Probably, the low level of CEP-specific Ab when a tumor burden is huge shows it is futile to apply the CEP-based vaccine.

Diabetes mellitus (DM) is associated with an increased rate of infection, which was partly explained by a decreased T cell-mediated response, and although being controversial, impaired function of neutrophil associated with diabetes is also documented. The purpose was to determine awareness of type 2 Diabetic patients about immunization against hepatitis-B, influenza, tetanus and zona, to find out the source of current vaccine information. The study was planned as a single centred, prospective, cross-sectional, descriptive and analytical trial. The questionnaire form was applied to patients diagnosed with type 2 DM, who applied to Diabetics Outpatient Clinic by face-to-face interview technique. Results. A total of 439 patients was evaluated; the diagnosis time of 38,5, 19, 24 and 18 % of the patients was determined as 0 - 5 years, 6 - 10 years, 11 - 15 years and more than 16 years, respectively. Organ damage was detected in 76 of the patients, and as the most common complication, retinopathy was found to be in 57 (13,01 %) patients. Among the patients, 175 (39,86 %) of them had coexisting hypertension, and 164 (37,36 %) of them had coexisting hyperlipidaemia. Whereas 153 (35,75 %) were aware of pneumococcal vaccine, the number of patients who got vaccinated was 55 (12,53 %). Whereas 336 (76,54 %) were aware of influenza vaccine, 108 (24,60 %) of them got vaccinated. Among the patients, 179 (40,77 %) heard of hepatitis B vaccine, but 34 (7,74 %) got vaccinated. It was determined that, 279 people heard od tetanus vaccine, 183 people were administered at least one dose of vaccine, however the last vaccine of 101 (55,49 %) of those who had tetanus vaccine, was more than 11 years ago. Only 3 out of 33 (7,52 %), who knew about the zona vaccine, got vaccinated. In that study, 243 (55,35 %) people got vaccinated in adulthood for any reason. There was no significant relationship between education level and duration of disease and vaccination. Conclusions. Adult immunization rates of diabetic patients were found to be in low levels. The primary care professionals play an essential role in the immunization of diabetic patients.